Strings 2008 2 7: Difference between revisions

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[[Image:Mut4.gif|nucleotide substitution]]
[[Image:Mut4.gif|nucleotide substitution]]


(Image from: [http://www2.mrc-lmb.cam.ac.uk/groups/ph1/mutmam.html Mimicking Affinity Maturation]
(Image from: [http://www2.mrc-lmb.cam.ac.uk/groups/ph1/mutmam.html Mimicking Affinity Maturation])


--[[User:ThomasHuber|ThomasHuber]] 15:29, 10 January 2008 (EST)
--[[User:ThomasHuber|ThomasHuber]] 15:30, 10 January 2008 (EST)

Revision as of 04:30, 10 January 2008

Evolutionary changes

  • DNA sequences typically change very slowly
    • e.g. 2*10-9 /base/year
  • changes are not equally likely to persist everywhere
    • some genomic regions may be mutated repeatedly while others remain unchanged.
  • nucleotide changes are not equal likely
    • Transitions (interchanges of purines (A⇔G) or of pyrimdines (C⇔T)) are more likely
    • Transversions (interchanges between purines and pyrimdines) are less likely

nucleotide substitution

(Image from: Mimicking Affinity Maturation)

--ThomasHuber 15:30, 10 January 2008 (EST)