Strings 2008 2 7

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Evolutionary changes

  • DNA sequences typically change very slowly
    • e.g. 2*10-9 /base/year
  • changes are not equally likely to persist everywhere
    • some genomic regions may be mutated repeatedly while others remain unchanged.
  • nucleotide changes are not equal likely
    • Transitions (interchanges of purines (A⇔G) or of pyrimdines (C⇔T)) are more likely
    • Transversions (interchanges between purines and pyrimdines) are less likely

nucleotide substitution

(Image from: Mimicking Affinity Maturation)

goto Substitution matrices

--ThomasHuber 15:30, 10 January 2008 (EST)