Pyridoxal Phosphatase structure: Difference between revisions
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[[Image:DALI_2cfsA_Updated.jpg|left|thumb|500px|The results obtained when 2cfsA was re-run against the DALI database]] | [[Image:DALI_2cfsA_Updated.jpg|left|thumb|500px|The results obtained when 2cfsA was re-run against the DALI database]] | ||
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'''"Inconsistencies" - flaw or strength?''' | |||
The second DALI run does not affect the results as PROFUNC has already indicated 2cftA to be the most closely-related to 2cfsA. On the contrary, the results serve as a confirmation that 2cfsA is indeed a Pyridoxal Phosphatase and belongs to the same family as 2oycA and 2cftA - two proteins that have been studied to assist in the structural and functional prediction of 2cfsA. | The second DALI run does not affect the results as PROFUNC has already indicated 2cftA to be the most closely-related to 2cfsA. On the contrary, the results serve as a confirmation that 2cfsA is indeed a Pyridoxal Phosphatase and belongs to the same family as 2oycA and 2cftA - two proteins that have been studied to assist in the structural and functional prediction of 2cfsA. | ||
[[Pyridoxal Phosphatase| Back To Main Page]] | [[Pyridoxal Phosphatase evolution| Back [Evolution]]] | [[Pyridoxal Phosphatase function| Next [Function]]] | [[Pyridoxal Phosphatase| Back To Main Page]] | [[Pyridoxal Phosphatase evolution| Back [Evolution]]] | [[Pyridoxal Phosphatase function| Next [Function]]] |
Revision as of 10:19, 8 June 2008
Importance of structural studies - the relationship between Evolution, Structure and Function.
- Protein evolution provides information pertaining to families of structurally related proteins, BUT sequence identities may be low.
- Structural studies help to identify unanticipated relationships in known structures.
- Functions can be assigned based on structural studies.
![](/mediawiki/upload/thumb/7/78/2cftA_Structure_breakdown.jpg/500px-2cftA_Structure_breakdown.jpg)
DALI - 1st Run
Based on the results of the first run, how similar is 2oycA to 2cfsA? With the aid of PyMOL, 2oycA was super-imposed against 2cfsA...
Comparing 2oycA against 2cfsA
1. Secondary Structure
2. Topology Diagram
PROFUNC
Related Protein Sequences in the PDB (SAS)
Matches to existing PDB Structures
Secondary Structure Matching (SSM)
![](/mediawiki/upload/thumb/0/0a/LIGPLOT_2cftA.jpg/400px-LIGPLOT_2cftA.jpg)
Dali - 2nd Run
"Inconsistencies" - flaw or strength?
The second DALI run does not affect the results as PROFUNC has already indicated 2cftA to be the most closely-related to 2cfsA. On the contrary, the results serve as a confirmation that 2cfsA is indeed a Pyridoxal Phosphatase and belongs to the same family as 2oycA and 2cftA - two proteins that have been studied to assist in the structural and functional prediction of 2cfsA.