Pyridoxal Phosphatase structure

General structure of Pyridoxal Phosphatase

Fig 1. Courtesy (and edited) of Almo et al., 2007. This structure is actually that of 2cftA - Human Pyridoxal 5'-Phosphate Phosphatase with its substrate. It is similar to 2cfsA, with the differences being the presence of a PLP ligand and the type of metal ions (2cfsA has magnesium ions, 2cftA has calcium ions). Notice the similarities between the structure of 2cftA and 2cfsA (Fig 2.).

Fig 2. The three-dimensional structure of 2cfsA, as generated by PyMOL

Red - Helix
Yellow - Sheet
Green - Loop

DALI - 1st Run

Fig 3. Significant hits as generated from the DALI database

Based on the results of the first run, how similar is 2oycA to 2cfsA? With the aid of PyMOL, 2oycA was super-imposed against 2cfsA...

Comparing 2oycA against 2cfsA

1. Secondary Structure

2. Topology Diagram

Topology Diagram of 2cfsA

Topology diagram of 2oycA

2

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