Pyridoxal Phosphatase function
Vitamin B6, Pyridoxal Phosphatase,
General Annotation
Known Functions
Amino Acid Metabolism
2cfsA is involved in almost all amino acid metabolism. Some of these amino acid metabolism include transamination, transsulfuration, selenoamino acid metabolism and conversion of typtophan to niacin.
Gluconeogenesis
2cfsA can catalyse transamination reactions that are essential for providing amino acids as a substrate for gluconeogenesis. 2cfsA is also required as a coenzyme for glycogen phosphorylase, which in turn catalyse glycogenolysis.
Neurotransmitter Synthesis
Pyridoxal phosphate-dependent enzymes catalyses the biosynthesis of serotonin, epinephrine, norepinephrine and gamma-aminobutyric acid(The four important neurotranmsitters).
Histamine Synthesis
2cfsA is involved in the metabolism of histamine.
Hemoglobin Synthesis and Function
Pyridoxal phosphate aids in the synthesis of heme and can also bind to two sites on hemoglobin to enhance the oxygen binding of hemoglobin.
Gene Expression
Pyridoxal phosphate has been implicated in increasing or decreasing the expression of certain genes. Increased intracellular levels of 2cfsA will lead to a decrease in the transcription of glucocorticoid hormones. Also, vitamin B6 deficiency will lead to the increased expression of albumin mRNA. Also, pyridoxal phosphate will influence gene expression of glycoprotein IIb by interacting with various transcription factors. The result is inhibition of platelet aggregation.
Sequence homology
Structural Similarities
Location of Gene on Genome
Functional Expression in Tissue
Protein-Protein Interactions
Functional Prediction:
Cofactor of HSPD1 and play a role in protein folding.
Coenzyme for asparagine synthetase by interacting with TS11.
Back To Main Page | Back [Structure] | Back to BIOL3004 2008