Phostphatase
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Phosphatase
MSA of the 2gfh with 35 others proteins. Only the 60th – 70th and the 210th -300th amino acid
sequence were shown to illustrate the conserved and invariant regions. The 3 boxed-up sequences were either conserved or invariant regions.
- 1st - aspartic acid (D)
- 2nd - threonine (T), asparagine (N) and glycine (G)
- 3rd - lysine (K) and aspartates (D)
- MSA corelate with with study done by Maliekal et al
- N-acetylneuraminic acid phosphatase orthologs shared 3 motifs found in phosphatases
- HAD (Haloacid dehalogenase-like) family
- Phosphatase activity: CO–P bond hydrolysis
- Dehalogenase activity: C–halogen bond hydrolysis
- Phosphonatase: C–P bond hydrolysis
- Phosphoglucomutase: CO–P bond hydrolysis and intramolecular phosphoryl transfer