Cellular context (location)
The expression profile of Fascin-1 is consistent with its function. the expression profile is shown below in Figure 1.
Figure One: Expression profile for fascin-1. Reproduced from GNF SymAtlas (Genomics Institute of Novartis Research Foundation. o http://symatlas.gnf.org/SymAtlas/symquery?q=71743)
We can observe from the graph that highest levels of fascin-1 are prsent in B-lymphoblasts which are immature cells which typically differentiate to form mature lymphocytes. B lymphocyte activation is accompanied by extensive membrane ruffling and pseudopod formation, which appears to be mediated by fascin (Tseng, 2001).