Cellular context (location)

The expression profile of Fascin-1 is consistent with its function. the expression profile is shown below in Figure 1.

Figure One: Expression profile for fascin-1. Reproduced from GNF SymAtlas (Genomics Institute of Novartis Research Foundation. o http://symatlas.gnf.org/SymAtlas/symquery?q=71743)

We can observe from the graph that highest levels of fascin-1 are prsent in B-lymphoblasts which are immature cells which typically differentiate to form mature lymphocytes. B lymphocyte activation is accompanied by extensive membrane ruffling and pseudopod formation, which appears to be mediated by fascin (Tseng, 2001).

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