DAP Functional Analysis

This image is chain A. Green shows the predicted active site residues His82 and His401. Pink shows Histidine residues that are also necessary for optimal enzymatic function, and experimentally mutations greatly reduce kcat. Blue is His313 predicted to be involved in subunit-subunit interactions. Red are Aspartyl and Glutamyl residues which are highly conserved across species and thought to participate in catalytic activity.