Divergence of function
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From LOCATE, --> mouse enzyme is found in cytosol and mitochondria
However, the human enzyme is found in the nucleus. --> Has a nuclear signal localization that is also found in yeast IPTs. --> This is not found in Bacillus halodurans(2qgn) --> Signal peptide sequence is found in the additional residues in humans and yeast. --> This may be the reason why human IPT is found in nucleus.
The different cellular location of the enzyme => different function
