HAD
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- HAD (Haloacid dehalogenase-like) family
- Phosphatase activity: CO–P bond hydrolysis
- Dehalogenase activity: C–halogen bond hydrolysis
- Phosphonatase: C–P bond hydrolysis
- Phosphoglucomutase: CO–P bond hydrolysis and intramolecular phosphoryl transfer
- HAD family
- Dependent on the presence of Mg2+
- Inhibited by vanadate and Ca2+
- E. coli genome encodes
- 23 soluble HAD-like hydrolases
- Representing about 40% of the E. coli
- Metabolites are intermediates of various metabolic pathways and reactions
- Glycolysis, pentose phosphate pathway, gluconeogenesis, and intermediary sugar and nucleotide metabolism
