HAD

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  • HAD (Haloacid dehalogenase-like) family
    • Phosphatase activity: CO–P bond hydrolysis
    • Dehalogenase activity: C–halogen bond hydrolysis
    • Phosphonatase: C–P bond hydrolysis
    • Phosphoglucomutase: CO–P bond hydrolysis and intramolecular phosphoryl transfer


  • HAD family
    • Dependent on the presence of Mg2+
    • Inhibited by vanadate and Ca2+


  • E. coli genome encodes
    • 23 soluble HAD-like hydrolases
    • Representing about 40% of the E. coli
    • Metabolites are intermediates of various metabolic pathways and reactions
    • Glycolysis, pentose phosphate pathway, gluconeogenesis, and intermediary sugar and nucleotide metabolism


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