Information

Domains

• Metazoans
  • DPCK and PPAT in a bifunctional form. Coded for by coasy.
  • Additional DPCK domain that is bacterial in origin.

• Bacteria
  • DPCK domain coded for by CoaE.
  • PPAT domain coded for by CoaD.
  • Two monofunctional enzymes.

• DPCK domain of coasy similar to DPCK domain of coaE.

Findings

• DPCK domain of metazoans and non-metazoans the only section of the alignment where both metazoans and non-metazoans have some sequence conservation.
• PPAT domain has no conservation between metazoan ans non-metazoan species in the alignment.

• The DPCK domain has ATP and ACO binding sites. These binding sites show sequence conservation throughout the mammalian species.

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