Information

Domains

Metazoans - DPCK and PPAT in a bifunctional form. Coded for by coasy.

         - Additional DPCK domain that is bacterial in origin.

Bacteria - DPCK domain coded for by CoaE.

         - PPAT domain coded for by CoaD.
         - Two monofunctional enzymes.

-DPCK domain of coasy similar to DPCK domain of coaE.

Findings

-DPCK domain of metazoans and non-metazoans the only section of the alignment where both metazoans and non-metazoans have some sequence conservation. -PPAT domain has no conservation between metazoan ans non-metazoan species in the alignment.

-The DPCK domain has ATP and ACO binding sites. These binding sites show sequence conservation throughout the mammalian species.