Michael Structure work

Week 4 work

SCOP structural protein classification info:

Protein: Fascin from Human (Homo sapiens) [TaxId: 9606]

Lineage:

1. Root: scop

2. Class: All beta proteins

3. Fold: beta-Trefoil barrel, closed; n=6, S=12; and a hairpin triplet; meander

4. duplication: has internal pseudo threefold symmetry Superfamily: Actin-crosslinking proteins

5. Family: Fascin

6. Protein: Fascin duplication: tandem repeat of four domains

7. Species: Human (Homo sapiens) [TaxId: 9606] [50408]

Interpro stuff:

This family consists of several eukaryotic fascin or singed proteins. The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles. The cortical structures, which include filopodia, spikes, lamellipodial ribs, oocyte microvilli and the dendrites of dendritic cells, have roles in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture [1].