Phostphatase

MSA of the 2gfh with 35 others proteins. Only the 60^th – 70^th and the 210^th -300^th amino acid

sequence were shown to illustrate the conserved and invariant regions. The 3 boxed-up sequences were either conserved or invariant regions.

• 1st - aspartic acid (D)

• 2nd - threonine (T), asparagine (N) and glycine (G)

• 3rd - lysine (K) and aspartates (D)

• MSA corelate with with study done by Maliekal et al
  • N-acetylneuraminic acid phosphatase orthologs shared 3 motifs found in phosphatases

• HAD (Haloacid dehalogenase-like) family
  • Phosphatase activity: CO–P bond hydrolysis
  • Dehalogenase activity: C–halogen bond hydrolysis
  • Phosphonatase: C–P bond hydrolysis
  • Phosphoglucomutase: CO–P bond hydrolysis and intramolecular phosphoryl transfer

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