Siowei

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Results on Function Analysis

Table 2.1 Complete annotation of NUBP2 retrieved from UnitProtKB/Swiss-Prot


Names and origin


Protein names Nucleotide-binding protein 2 Also known as:     NBP 2
Gene names
Name:  NUBP2


Organism Homo sapiens (Human)

General annotation (Comments)


Function May contribute to formation of bipolar spindles (By similarity).
Subunit structure Binds NUBP1 and KIFC1 (By similarity).
Subcellular location Nucleus (By similarity). Note=Associated with nucleus during interphase and nucleocytoplasm surrounding mitotic spindles during early mitosis. Enriched around centrosomes during late mitosis (By similarity).
Tissue specificity Widely expressed with highest expression in skeletal muscle.
Developmental stage Expressed in fetal brain, lung, liver and kidney.
Sequence similarities Belongs to the Mrp/NBP35 ATP-binding proteins family.

Ontologies


Keywords
   Cellular component Nucleus
   Ligand ATP-bindingNucleotide-binding
Gene Ontology (GO)
   Molecular function Nucleotide binding

Traceable author statement. Source: ProtInc

Sequence annotation (Features)


Feature key Position(s) Length Description
Molecule processing
Chain
271
Nucleotide-binding protein 2


Regions
Nucleotide binding
8
ATP Potential


Table 2.2 Aligned sequence of 2ph1 protein

Ali.jpg



Table 2.3 The diagram and table below show the 3 sequence motifs found in the sequence


3seq.jpg 3seq1.jpg


Table 2.4 The diagram and table below show the 1 sequence of superfamily found in the sequence


Seq1.jpg

Seq2.jpg


Figure 1. Protein-protein interactions search using 2ph1 sequence


Inter1.jpg



Input1.jpg

Figure 2. Protein-protein interactions search using NUBP2 sequence


Inter2.jpg



Input2.jpg


Figure 3. NUBP2 expressions in human and mouse tissues


Exp.jpg