Strings 2008 2 7: Difference between revisions
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[[Image:Mut4.gif|nucleotide substitution]] | [[Image:Mut4.gif|nucleotide substitution]] | ||
(Image from: [http://www2.mrc-lmb.cam.ac.uk/groups/ph1/mutmam.html Mimicking Affinity Maturation] | (Image from: [http://www2.mrc-lmb.cam.ac.uk/groups/ph1/mutmam.html Mimicking Affinity Maturation]) | ||
--[[User:ThomasHuber|ThomasHuber]] 15: | --[[User:ThomasHuber|ThomasHuber]] 15:30, 10 January 2008 (EST) | ||
Revision as of 04:30, 10 January 2008
Evolutionary changes
- DNA sequences typically change very slowly
- e.g. 2*10-9 /base/year
- changes are not equally likely to persist everywhere
- some genomic regions may be mutated repeatedly while others remain unchanged.
- nucleotide changes are not equal likely
- Transitions (interchanges of purines (A⇔G) or of pyrimdines (C⇔T)) are more likely
- Transversions (interchanges between purines and pyrimdines) are less likely
(Image from: Mimicking Affinity Maturation)
--ThomasHuber 15:30, 10 January 2008 (EST)
