Fascin Introduction

Intro

Actin bundles are necessary for the formation of specialized cellular processes, intercellular communication, and cell migration. Actin binding proteins guide the reorganization of the cytoskeleton that underlie these processes.

Fascins bundle actin filaments into large, tightly packed hexagonal arrays that support diverse cellular processes including microvillar projections and filopodial extensions at the leading edge of migratory cells and that has been implicated in cell motility in several cell types (Jawhari et al 2003). Fascin should contain two actin binding domains since the protein cross-links actin filaments as a monomer (Cant & Cooley 1995). Fascin is widely expressed including the brain, blood, colon, lung, breast, ovary, and testis. In the brain, fascin expression has been localized to neurons, glial cells, and endothelial cells.(Nagai et al. 2008)

One actin binding site is contained within the C-terminal half of fascin. This 21 amino acid region is a highly conserved domain is hydrophobic (Cant & Cooley 1995).

Abstract | Introduction | Methods | Results | Discussion | Conclusion | Appendix | References
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